Dexazine

Dexamethasone is a synthetic corticosteroid and possesses glucocorticoid activity Dexamethasone sodium phosphate is a salt of dexamethasone that is particularly suitable for intravenous administration because it is highly water soluble, permitting administration of relatively large doses in a small volume of diluent.

Category:

Description

Dexazine

Dexamethasone Sodium Phosphate Injection 0.2%

 

(For Veterinary Use Only)

COMPOSITION:

Contains per ml.

Dexamethasone Sodium Phosphate2mg

Excipients Ad 1 ml

DESCRIPTION

This product is a colorless clear liquid.

PHARMACOLOGICAL ACTION

Dexamethasone is a synthetic corticosteroid and possesses glucocorticoid activity Dexamethasone sodium phosphate is a salt of dexamethasone that is particularly suitable for intravenous administration because it is highly water soluble, permitting administration of relatively large doses in a small volume of diluent. Dexamethasone, as a steroid, is equivalent in potency to some established steroids while being considerably more potent than others. In the case of the dog, dexamethasone is found to be about equivalent in dosage to prednisone but about 30 to 40 times more potent than prednisolone.

TARGET SPECIES

Horses, cattle, sheep, pigs, dogs, cats.

INDICATION

Myoglobinuria, allergic reaction, urticaria, toxinaernia, shock and hepatitis. Local treatment of arthritis, bursitis, distortions, tendinitis, tendovaginitis, and peri-arthritis.

USAGE AND DOSAGE

For intramuscular, intravenous administration:

Cattle and horses 1ml per 25kg body weight

Cats and dogs 1ml per 10kg body weight

CONTRAINDICATIONS

Diabetes mellitus, osteoporosis, heart and kidney dysfunction, Do not inject during the last (third) part of gestation.

INTERACTIONS

  1. Liver drug enzyme inducers such as phenobarbital can promote the metabolism of these drugs and reduce their efficacy.
  2. It can accelerate the elimination of salicylates, reduce their efficacy, and can also cause gastrointestinal ulcers when combined.
  3. The therapeutic effect of taking anticoagulants orally can be reduced, and when the two are used together, the dosage of anticoagulants should be appropriately increased.
  4. Thiazide diuretics can promote potassium excretion, and when combined, attention should be paid to supplementing potassium.

SIDE EFFECTS

The therapeutic use of dexamethasone sodium phosphate injection is unlikely to cause undesired accentuation of metabolic effects. However, if continued corticosteroid therapy is anticipated, a high protein intake should be provided to keep the animal in a positive nitrogen balance. A retardant effect on wound healing should be considered when it is used in conjunction with surgery. Euphoria an improvement of attitude, and increased appetite are the usual manifestations.

Side effects such as glycosuria, hyperglycemia, diarrhea, polydipsia, and polyuria have been observed in some species.

Side effects such as SAP and SGPT enzyme elevations, eosinopenia, and vomiting have occurred following the use of synthetic corticosteroids in dogs.  Cushing’s Syndrome in dogs has been reported in association with prolonged or repeated steroid therapy. Corticosteroids reportedly cause laminitis in horses.

PRECAUTION

Corticosteroids are not recommended for use in pregnant animals.

WITHDRAWAL TIME

Meat:                      21 days

Milk:                        72 hours

PACKING

Type II glass vials of 50 and 100ml capacity stoppered with grey butyl rubber stoppers and capped with center tear off aluminum crimp seal and flick-off caps

SHELF LIFE

3 years

STORAGE

Below 30°C, Store in a dry and cool place and protect from light.

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